Does Kratom Reduce Inflammation? An Overview

Does Kratom Reduce Inflammation? An Overview

05 Apr

Here’s the question that most people ask. Does kratom reduce inflammation? Does it help or have a noticeable effect? To understand the answer to this question, let’s look at the pharmacology of kratom. If you don’t already know what’s inside kratom, the compounds will help you glean insight into kratom’s reduction of inflammation.

Kratom contains more than 40 compounds. Some are alkaloids and others are flavonoids. However, in total, there are two particular alkaloids (mitragynine and 7-hydroxymitragynine) that impact the many benefits of kratom. Those alkaloids (and some of its flavonoids) play a big role in kratom’s opioid receptor responses to things like inflammation and pain.

Alkaloids such as Ajmalicine help with hypertension. Other alkaloids, like the ever-prevalent, mitragynine, assists with opioid withdrawals by providing a euphoric effect. 7-hydroxymitragynine has analgesic properties to help battle severe pain. Most of these alkaloids work by binding to the mu-opioid receptors in our brains, spinal cords and sensory neurons.

While a lot is known about all the compounds in kratom, studies still haven’t uncovered the full impact of its pharmacology. That make kratom more of a wild card. Since it’s not classifiable as an opiate, yet it has opioid effects, it’s confused many local and national governments around the world, some of who’ve banned kratom.

 

What Is Kratom?

Kratom is an evergreen tree from the coffee family. It grows in Southeast Asia, in countries like Malaysia and Indonesia. Indigenous tribes have used it medicinally for hundreds of years by. In cultures where kratom grows, it’s often consumed by chewing on its leaves.

People looking to avoid alcohol use kratom in several countries. It’s boiled along with cough syrup and coca-cola, and subsequently adding ice. The younger crowd uses this so-called, kratom drink for its euphoric effects. Muslims in Southeast Asia who cannot drink alcohol also use it.

The official name for kratom is Mitragyna Speciosa. It grows in tropical climates that are humid, usually found in rainforests with higher-than-average temperatures but not much direct sunlight.

 

What Is Inflammation?

Swelling, redness, even soreness are symptoms of inflammation. Often, this is a reaction to an injury, or even an infection. Inflammation is a sign that the body is working to help eliminate damaged cells from the body. This often involves the immune cells and immune system of the body, along with molecular mediators.

Inflammation can be broken down into 5 different classes, which are “heat, pain, redness, swelling and loss of function.” It can also be described as chronic inflammation or acute inflammation. Acute inflammation is the body’s initial response to the damaged cells or injured tissues through the blood vessels via leukocytes and plasma.

Chronic inflammation is persistent and sticks around for a long time. Most people who are turning to kratom to reduce their inflammation are often battling chronic inflammation. This is usually the result of a serious injury or degradable pathogens, viral infections and autoimmune diseases.

Some examples of chronic inflammation are rheumatoid arthritis and other forms of arthritis, as well as fibromyalgia, joint and musculoskeletal related. Redness, swelling, severe joint pain and stiffness are clearly symptoms of this.

Other antioxidants and foods can reduce inflammation, but none that have the largely potent effect that kratom has on reduction of inflammation. Often, kratom reduces swelling and inflammation for 3 to 5 hours after taking it.

 

How Does Kratom Reduce Inflammation?

Two of the those compounds have a big impact on kratom’s ability to reduce inflammation (one is a flavanoid and the other an alkaloid).

  • Epicatechin: Epicatechin is an antioxidant that acts as an anti-inflammatory. It also works to prevent cancer. Antioxidants naturally inhibits oxidation, a process which can damage the body’s cells. This creates a balance, or harmony, in the body while also combating naturally helping reduce disease.
  • Rhynchophylline: This alkaloid is described as a “non-competitive NMDA antagonist.” NMDA is found in nerve cells. Antagonists are opioid inhibitors. They bind to the opioids without actually activating, or turning them on. While there’ve been very few clinical trials using Rhynchophylline, the consensus is that it reduced things like hypertension and lightheadedness primarily because it works to reduce inflammation.

Kratom has many anti-inflammatory properties. As an organic, herbal supplement, the benefits of taking kratom, not only for inflammation, but also for pain, depression and others seems to be a more sought-after route to potentially harmful prescription drugs.

Another one of the alkaloids present in kratom is 7-hydroxymitragynine, which works as both a pain killer and a vasodilator. Vasodilators allow blood to flow easily through the body’s arteries and veins, preventing things like hypertension. The pharmacology of kratom across the board works to reduce inflammation in extraordinary ways.

 

Should you used kratom to reduce inflammation?

If you’re dealing with serious inflammation, many users have reported that kratom was effective in helping to reduce that inflammation. However, while kratom does have many benefits, it also has numerous side effects. Be sure to look into those before buying kratom.

If you’ve never used kratom before, it’s best to start with kratom tea. However, if you’re battling a serious disease that invites major inflammation, it might be better to utilize kratom powder or even the extract variant. The extract is extremely potent. So acclimate yourself to kratom before trying that.

Overall, kratom does promote healing, while also naturally aiding with severe pain and opioid withdrawals. But if you’ve never used it before, be wary of taking too much. You could end up feeling incredibly sick, vomiting uncontrollably for hours, feeling dizzy, and so on.

 

How much kratom should you buy?

If you’re looking to reduce inflammation with kratom, how much should you buy? If you’ve never taken kratom before, then buying in bulk might not be the right step until your body is acclimated to it. However, if kratom proves helpful, buying kratom in bulk will get you better prices.

Keep in mind that there are different strains that you can purchase. Each of those strains might have a slightly different impact on you. Some have a different alkaloid profile than others. Mainly, that means that some are rich in one alkaloid over another, or oftentimes, even both alkaloids. Those two alkaloids that have the largest impact on its effect are mitragynine and 7-hydroxymitragynine.

 

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