Red-vein kratom is the most abundantly harvested and consumed kratom variety in existence. Currently, it outstrips both the green and white-veined kratom combined. The reason? Red-vein kratom (red kratom for short) has both medicinal properties and euphoric properties. However, it’s most sought-after for its pain-reliving effects. Yet it does more than just relieve pain. It relaxes and soothes you, putting your mind at ease.
Red-vein kratom binds to the mu-opioid receptor. It’s a partial agonist. In that aspect, it’s similar to other opiates. but without the activation of serotonin. Yet, the euphoric sensations come from the partial release of dopamine, a neurotransmitter in the brain. Yet, binding to the mu-opioid receptor, and the delta-opioid receptor, gives it its analgesic properties. That’s thanks in part to the large presence of 7-HMG (7-Hydroxymitragynine).
If you take kratom, or you’re planning on buying it at some point in the near future, this information could likely pose invaluable. Depending on what ails you, you’ll need to select the right kratom strain for you. But it’s not just the strain. It’s the vein, the strain, the region, all of it. There’s are different effects with nearly each one, and they aren’t always consistent. Some red-vein kratom strains will do less of the pain-relieving or sedation, and provide more stimulation or alertness.
It all depends on what you go with. However, when talking about the general effects of red-vein kratom, there are many commonalities. Since red kratom has a majority of 7-HMG present, there are significant analgesic properties when compared to white-veined kratom. White-veined kratom has an abundance of the other alkaloid, mitragynine, which provides more of a euphoric effect.
Red Vein Kratom Effects Explained
The 7-HMG alkaloid is a partial agonist at the mu-opioid receptor. That just means it’s a chemical that binds to a receptor and activates it. 7-HMG has less of an affinity to the opioid receptor and the kappa-opioid receptors. However, 7-HMG differs from mitragynine because it’s far more potent. In fact, it’s been estimated that it’s 30-fold more potent than its mitragynine counterpart. And also 17-fold more potent than morphine at this receptor. However, it’s a partial agonist. What does that mean?
When we’re talking about the effects of red vein kratom, when need to look at the primary alkaloid, 7-HMG, which is powerful. 7-HMG’s binding to the mu-opioid receptor is also very indicative of the response. The mu-opioid receptor is located in the brain, the spinal cord and in the peripheral sensory neurons. There are three mu-opioid receptor types which are responsible for the following:
- Mu(1) – Analgesic (pain relief) and physical dependence
- Mu(2) – Respiratory depression, miosis (pupil constriction), euphoria, reduced GI motility (constipation) and physical dependence
- Mu(3) – Vasodilation (increased blood flow)
However, since 7-HMG is a partial agonist, unlike morphine, which is a full agonist, the effects are far more subtle and less powerful than morphine. But, considering that it is a partial agonist (activator) you do have the pain-relief properties (but not as strong as morphine) and you do have the euphoric properties (but less enhanced than white-veined kratom).
Another thing to note here about the effects of red vein kratom are the potential for physical dependence. Since it’s a partial activator of the receptor, and 2 of these three sub-receptors are responsible for physical dependence, the excessive use of red vein kratom can lead to physical dependency. So be careful of how much you use it unless you’re willing to risk physical depdency.
Pain Relief Effect
Most of the kratom research points to the fact that red vein kratom has less mitragynine than it does the 7-HMG alkaloid. While there are over 25 alkaloids (and 40+ compounds) in kratom, red vein kratom’s primary effects from the presence of 7-HMG in high doses. This is often referred to as the pain-killing alkaloid. Since it’s a partial agonist of the mu-opioid receptor, and the mu-opioid’s receptor is primarily an analgesic, it will kill pain.
Thus, if you have pain, red vein kratom is the preferred variety. Now, consider that some strains are more effective at this than others so you’ll need to do some due diligence. For example, Red Vein Indo and Red Vein Bali are very effective at pain relief while some other strains are not as potent. You might need to experiment with a few varieties and doses to see what the best red vein kratom might be for you.
Other red vein kratom strains include the likes of Red Vein Sumatra, Red Maeng Da and Red Vein Borneo. Red Vein Borneo is not as sedative as Red Vein Bali, for example. However, it does allow you to relax.
Red Vein Kratom Sedation Effect
For the most part, when we’re talking about pain relief, we’re talking about sedation. However, some strains of red vein kratom are more sedative (calming) than others. But this is a big part that comes along with the partial activation of the mu-opioid receptor. While the term “analgesic” does mean to dull pain, dulling pain is, in effect, sedative. However, that isn’t always the case for sedative drugs. For example, the drug, Ambient does not kill pain but it does sedate you.
Some other pain killers, such as morphine, act as a sedative as well. Morphine, of course, is very powerful. Some people are seeking the powerful pain killing and sedative powers of certain strains of red vein kratom, but not all. In fact, some people don’t want to chase a potential high for fear of its potential for addictive tendencies to develop. However, for those dealing with serious chronic pain, red vein kratom strains that are very potent are definitely preferred to their less potent counterparts.
Clearly, red-vein kratom is used for pain. That’s obvious because of the large presence of 7-HMG. However, red vein kratom effects also stem into opioid withdrawal treatment. Keep in mind that there is still mitragynine present in red vein kratom. And mitragynine is responsible more so for the opioid withdrawals because of its euphoric effects. Now, not all red vein kratom effects include euphoria.
However, the strains that do have more mitragynine will certain assist with opioid withdrawals. But, considering that 4 to 5 million Americans are using kratom, and that red vein kratom outsells both white and green vein kratom, it’s pretty clear that it’s being used across the board in states where kratom is legal.