One question that most people have when it comes to kratom is about its alkaloid profile. Of course, pharmacology is important. It determines the benefits and side effects and gives you a deeper understanding of the physiological impact kratom can have. By understanding kratom’s alkaloid profile, you’ll also gain insight into just how much of its pharmacology is attributed to various biological responses.
I don’t know about you, but I’m acutely interested in understanding things on a deeper level. However, kratom is one of those substances that lacks in-depth scientific research. That might be why most people don’t understand its alkaloid profile. But it’s this specific alkaloid profile that holds the key to understanding kratom on a deeper, more molecular level.
While controversy around this drug swirls, many swear by it. They wouldn’t live without it, in fact. And if you were to take that ability from them to use kratom, it would be destructive to say the least. However, maybe the answer lies in better understanding kratom’s pharmacology. Maybe that would eliminate some of the controversy surrounding it. And maybe it wouldn’t. But knowledge is most certainly power.
Kratom’s Alkaloid Profile
Kratom has a mixture of alkaloids. However, there are only a few alkaloids known to be in high concentration. These are the alkaloids that have the biggest impact. By understanding these alkaloids, you can largely understand why kratom’s physhiological effects. This is factual, steeped in deep science.
Mitragynine is possibly the most understood and well-studied alkaloid found in kratom’s alkaloid profile. There’s roughly 1% to 6% concentration of mitragynine within kratom, so it largely attributes much of its behavior. Mitragynine binds to the mu-opioid receptor as a selective agonist. It does not release serotonin, making it less harmful than opioids like heroin. But it does exhibit opioid-like behavior.
You can get addicted to kratom because of this biological response of binding to the mu-opioid receptor. That receptor, which is located in the brain, spinal cord and sensory neurons, carries the attribute of physical dependence. It’s also responsible for the euphoric effects you feel when you use kratom.
Roughly 6.6% to 7% concentration of speciogynine exists within kratom. It’s known simply as a smooth muscle relaxant. Clearly, in some kratom strains, this is prevalent due to the specific physiological effects this alkaloid exhibits.
Roughly 0.01% to 0.04% concentration exists of 7-hydroxymitragynine within kratom. However, this alkaloid is far more potent than morphine. In fact, it’s roughly 30 times more powerful than morphine.
Less than 1% concentration of 9-hydroxycorynantheidine, which is also a partial opioid agonist to the mu-opioid receptor.
Mitraphylline is a muscle relaxer and diuretic, and it’s also known as a vasodilator and an immunostimulant. Part of the vasodilation (enlarging of blood vessels) attributed to kratom comes from the presence of mitraphylline, which is less than 1% concentration within kratom.
Less than 1% concentration in Mitragynia Speciasa, Rhynchophylline is also found in Uncaria, also from the coffee family (Rubiaceae). This acts as an NMDA (a receptor found in nerve cells that largely controls memory functions) antagonist as well as a calcium channel blocker. An antagonist blocks or inhibits biological responses, meaning that this alkaloid is responsible for blocking NMDA.
Uncaria is chewed on by locals, similarly to how kratom is chewed on when picked directly from its parent tree, and has properties that help with things like hypertension and lightheadedness. However, Rhynchophylline is just one such alkaloid present within the Uncaria leaves.
Roughly 9% concentration of paynantheine in kratom, and it exhibits opioid like effects.
Less than 1% concentration of isomitraphylline exists in kratom. It’s known largely as an immunostimulant. In other words, it acts like a drug to stimulate the immune system.
Less than 1% concentration of isomitrafoline exists in the alkaloid profile of kratom. However, very little is known about this alkaloid.
Less than 1% concentration of corynantheidine is found in kratom. This alkaloid is also found in the Yohimbe tree from Central Africa.
Less than 1% concentration of isorhynchophylline, which is another immunostimulant to add to the alkaloid profile of kratom.
Less than 1% concentration of this alkaloid exists in kratom. Little is known about it.
Less than 1% concentration of ciliaphylline exists within the alkaloid profile of kratom. It’s an analgesic and antitussive (prevents coughs).
Less than 1% concentration. Ajmalicine is an anti-adrenergic alkaloid. It also acts as a smooth muscle releaxer and an anticonvulsant. Sometimes even a sedative.
Corynoxine A C22H28N2O4
Less than 1% concentration of corynoxine A exists in kratom.
Corynoxine B C22H28N2O4
Less than 1% concentration of corynoxine B exists in kratom.
Less than 1% concentration of speciophylline exists in kratom. It works as an anti-leukemic.
Less than 1% concentration of speciciliatine in kratom, which also works as a weak opioid agonist.
Tetrahydroalstonine is a hypoglycemic (lowers blood sugar), anti-adrenergic alkaloid. There’s less than a 1% concentration of it within kratom.
Less than 1% concentration of mitrafoline exists in the alkaloid profile of kratom.
Less than 1% concentration of akummigine exists in the alkaloid profile of kratom.
Less than 1% concentration of speciofoline exists in kratom. It acts as an analgesic (pain reliever) and an antitussive.
Less than 1% concentration of stipulatine exists in the alkaloid profile of kratom.
Less than 1% concentration of mitraversine exists within kratom.